Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission
in the United States. Chronic pancreatitis, although lower in incidence, significantly reduces …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of human cancer
for which there are no effective therapies. Deep sequencing of PDAC tumors has revealed …

Pancreatic acinar cells of adult mice (≥ P60) are resistant to transformation by some of the
most robust oncogenic insults including expression of K-Ras oncogenes and loss of …

Background Epidemiological studies have clarified the potential associations between
regular aspirin use and cancers. However, it remains controversial on whether aspirin use …

Chronic pancreatitis predisposes to pancreatic cancer development and both diseases
share a common etiology. A central role has been proposed for the digestive enzyme …

Pancreatic ductal adenocarcinoma (PDA) is one of the most devastating malignancies
worldwide. A total of 43,140 new cases (ranked 10th) and 36,800 deaths (ranked 4th) from …

Tumor is a representative of cell immortalization, while senescence irreversibly arrests cell
proliferation. Although tumorigenesis and senescence seem contrary to each other, they …

Pancreatic cancer (PC) is one of the most aggressive diseases. Only 10% of all PC cases
are thought to be due to genetic factors. Here, we analyzed the most recently published case …

Tobacco smoking represents an important known cause of ductal pancreatic
adenocarcinoma. Recent data from pooled analyses in consortia involving multiple case …

Pancreatic cancer (PC) is a highly lethal malignancy with near 100% mortality. This is in part
due to the fact that most patients present with metastatic or locally advanced disease at the …