Abstract Store-operated Ca 2+ entry (SOCE) is a Ca 2+ entry mechanism activated by
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …

Store-operated Ca2+ entry (SOCE) is a ubiquitous and essential mechanism regulating
Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including …

Background Store-operated Ca 2+ entry (SOCE) through Ca 2+ release–activated Ca 2+
channels is an essential signaling pathway in many cell types. Ca 2+ release–activated Ca …

Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-
function mutations in the Ca2+ release–activated Ca2+ (CRAC) channel genes ORAI1 and …

Ion channel is an integral membrane protein that allows the permeation of charge ions
across hydrophobic phospholipid membranes, including plasma membranes and organelle …

In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent,
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …

Immunity to fungal infections is mediated by cells of the innate and adaptive immune system
including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction …

Abstract Calcium (Ca2+) acts as a ubiquitous second messenger, and normal cell and tissue
physiology strictly depends on the precise regulation of Ca2+ entry, storage, and release …

The importance of calcium (Ca2+) as a second messenger in T cell signaling is exemplified
by genetic deficiencies of STIM1 and ORAI1, which abolish store-operated Ca2+ entry …

Abstract Store-operated Ca 2+ entry (SOCE) represents a predominant Ca 2+ influx pathway
in non-excitable cells. SOCE is required for immune cell activation and is mediated by the …