Update on the pathogenesis of chronic obstructive pulmonary disease
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Defining the relationship between COPD and CVD: what are the implications for clinical practice?
Cardiovascular diseases (CVDs) are arguably the most important comorbidities in chronic
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …
Cardiovascular disease in COPD: mechanisms
JD Maclay, W MacNee - Chest, 2013 - Elsevier
It is now well established that cardiovascular disease contributes significantly to both
morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD …
morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD …
Ageing and the border between health and disease
W MacNee, RA Rabinovich… - European Respiratory …, 2014 - Eur Respiratory Soc
Ageing is associated with a progressive degeneration of the tissues, which has a negative
impact on the structure and function of vital organs and is among the most important known …
impact on the structure and function of vital organs and is among the most important known …
Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Aging is a natural process characterized by progressive functional impairment and reduced
capacity to respond appropriately to environmental stimuli and injury. The incidence of two …
capacity to respond appropriately to environmental stimuli and injury. The incidence of two …
Mechanisms of cigarette smoke-induced COPD: insights from animal models
A Churg, M Cosio, JL Wright - American Journal of …, 2008 - journals.physiology.org
Cigarette smoke-induced animal models of chronic obstructive pulmonary disease support
the protease-antiprotease hypothesis of emphysema, although which cells and proteases …
the protease-antiprotease hypothesis of emphysema, although which cells and proteases …
Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: the Emphysema and Cancer Action Project (EMCAP) Study
RG Barr, S Mesia-Vela, JHM Austin… - American journal of …, 2007 - atsjournals.org
Rationale: Basic science research suggests a causal role for endothelial dysfunction in
chronic obstructive pulmonary disease (COPD). Clinical studies examining endothelial …
chronic obstructive pulmonary disease (COPD). Clinical studies examining endothelial …
Diffusion‐weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease
SS Kaushik, ZI Cleveland, GP Cofer… - Magnetic …, 2011 - Wiley Online Library
Given its greater availability and lower cost, 129Xe apparent diffusion coefficient (ADC) MRI
offers an alternative to 3He ADC MRI. To demonstrate the feasibility of hyperpolarized …
offers an alternative to 3He ADC MRI. To demonstrate the feasibility of hyperpolarized …
Expanding the Clinical Indications for α1-Antitrypsin Therapy
EC Lewis - Molecular medicine, 2012 - Springer
Abstract α 1-Antitrypsin (AAT) is a 52-kDa circulating serine protease inhibitor. Production of
AAT by the liver maintains 0.9-1.75 mg/mL circulating levels. During acute-phase responses …
AAT by the liver maintains 0.9-1.75 mg/mL circulating levels. During acute-phase responses …
What does endotyping mean for treatment in chronic obstructive pulmonary disease?
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease,
both at the clinical and biological level. However, COPD is still diagnosed and treated …
both at the clinical and biological level. However, COPD is still diagnosed and treated …