Microfluidic organ-on-a-chip models of human liver tissue
The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology
In the last decade microfabrication processes including rapid prototyping techniques have
advanced rapidly and achieved a fairly mature stage. These advances have encouraged …
advanced rapidly and achieved a fairly mature stage. These advances have encouraged …
Long‐term maintenance of a microfluidic 3D human liver sinusoid
The development of long‐term human organotypic liver‐on‐a‐chip models for successful
prediction of toxic response is one of the most important and urgent goals of the …
prediction of toxic response is one of the most important and urgent goals of the …
Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems
FT Lee-Montiel, SM George… - Experimental …, 2017 - journals.sagepub.com
This article describes our next generation human Liver Acinus MicroPhysiology System
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …
Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes
An important number of healthy and diseased tissues shows spatial variations in their
metabolic capacities across the tissue. The liver is a prime example of such heterogeneity …
metabolic capacities across the tissue. The liver is a prime example of such heterogeneity …
Disease modeling and gene therapy of copper storage disease in canine hepatic organoids
The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new
avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a …
avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a …
[HTML][HTML] Bio-tunable acoustic node assembly of organoids
Many tissues in the human body are composed of densely-packed cells and minimal
extracellular matrix (ECM). The resulting close cell proximity is important to retain cell …
extracellular matrix (ECM). The resulting close cell proximity is important to retain cell …
Progressive hypoxia‐on‐a‐chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease
YB Kang, J Eo, B Bulutoglu… - Biotechnology and …, 2020 - Wiley Online Library
Oxygen is vital to the function of all tissues including the liver and lack of oxygen, that is,
hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo …
hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo …
Fish scale-derived collagen patch promotes growth of blood and lymphatic vessels in vivo
In this study, Type I collagen was extracted from fish scales as a potential alternative source
of collagen for tissue engineering applications. Since unmodified collagen typically has poor …
of collagen for tissue engineering applications. Since unmodified collagen typically has poor …
Protein-based layer-by-layer films for biomedical applications
MH Iqbal, H Kerdjoudj, F Boulmedais - Chemical Science, 2024 - pubs.rsc.org
The surface engineering of biomaterials is crucial for their successful (bio) integration by the
body, ie the colonization by the tissue-specific cell, and the prevention of fibrosis and/or …
body, ie the colonization by the tissue-specific cell, and the prevention of fibrosis and/or …