Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …

The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …

Emerging respiratory coronaviruses such as the severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …

Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its
cellular source in the periphery remains poorly defined. Here we report a critical function for …

Aluminum hydroxide (alum) and the oil-in-water emulsion MF59 are widely used, safe and
effective adjuvants, yet their mechanism of action is poorly understood. We assessed the …

The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a
consequence of their localization within tissues and their specialized capacity for …

The morbidity and mortality associated with respiratory virus infection is felt most keenly
among the elderly. T cells are necessary for viral clearance, and many age-dependent …

Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …

The development of immunotherapeutic methods for the treatment of oncological diseases
have made it possible to improve the effectiveness of standard therapies. There was no …

CCR7-mediated migration of naive T cells into the secondary lymphoid organs is a
prerequisite for their encounter with mature dendritic cells, the productive presentation of …