Targeted protein degradation: from mechanisms to clinic
Targeted protein degradation refers to the use of small molecules to induce the selective
degradation of proteins. In its most common form, this degradation is achieved through …
degradation of proteins. In its most common form, this degradation is achieved through …
Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
The molecular cytoarchitecture of the adult mouse brain
J Langlieb, NS Sachdev, KS Balderrama, NM Nadaf… - Nature, 2023 - nature.com
The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …
diversely specialized cell types. Yet, the molecular identities of the cell types and their …
Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are key therapeutic agents in the
management of metastatic hormone-receptor-positive breast cancer. However, the …
management of metastatic hormone-receptor-positive breast cancer. However, the …
Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells
Proximity labeling proteomics (PLP) strategies are powerful approaches to yield snapshots
of protein neighborhoods. Here, we describe a multiscale PLP method with adjustable …
of protein neighborhoods. Here, we describe a multiscale PLP method with adjustable …
CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/proteasome-MAPK signaling pathway and enhancing …
MJ Zhang, M Shi, Y Yu, H Wang, R Ou, R Ge - Life Sciences, 2024 - Elsevier
Aims Curcumin is a natural compound and has good antitumor properties, but its clinical use
is limited by its low bioavailability. We constructed the derivative CP41 (3, 5-bis (2 …
is limited by its low bioavailability. We constructed the derivative CP41 (3, 5-bis (2 …
Exploring unconventional attributes of red blood cells and their potential applications in biomedicine
AT Anastasiadi, VZ Arvaniti, KE Hudson… - Protein & …, 2024 - academic.oup.com
Eukaryotic cells are defined as cells containing distinct nuclei and other membranous
organelles. However, red blood cells (RBCs) lack a nucleus and organelles—perhaps to …
organelles. However, red blood cells (RBCs) lack a nucleus and organelles—perhaps to …
Design patterns of biological cells
Abstract Design patterns are generalized solutions to frequently recurring problems. They
were initially developed by architects and computer scientists to create a higher level of …
were initially developed by architects and computer scientists to create a higher level of …
Viable mutations of mouse midnolin suppress B cell malignancies
Viable mutations of mouse midnolin suppress B cell malignancies | Journal of Experimental
Medicine | Rockefeller University Press Skip to Main Content Advertisement Umbrella Alt Text …
Medicine | Rockefeller University Press Skip to Main Content Advertisement Umbrella Alt Text …
Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis
The ubiquitin-proteasome system (UPS) governs the degradation of proteins by
ubiquitinating their lysine residues. Our study focuses on lysine deserts-regions in proteins …
ubiquitinating their lysine residues. Our study focuses on lysine deserts-regions in proteins …