The core machinery that drives the eukaryotic cell cycle has been thoroughly investigated
over the course of the past three decades. It is only more recently, however, that light has …

Progression through the eukaryotic cell cycle is known to be both regulated and
accompanied by periodic fluctuation in the expression levels of numerous genes. We report …

The Drosophila retina has a precise repeating structure based on the unit eye, or
ommatidium. This review summarizes studies of the cell proliferation and survival episodes …

The lats gene has been identified as a tumour suppressor in Drosophila melanogaster using
mosaic screens 1. Mosaic flies carrying somatic cells that are mutant for lats develop large …

We demonstrate that fizzy-related (fzr), a conserved eukaryotic gene, negatively regulates
the levels of cyclins A, B, and B3. These mitotic cyclins that bind and activate cdk1 (cdc2) are …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder leading to the
widespread development of benign tumors that often contain giant cells. We show that the …

Cell proliferation in animals must be precisely controlled, but the signaling mechanisms that
regulate the cell cycle are not well characterized. A regulated terminal mitosis, called the …

Spatially and temporally choreographed cell cycles accompany the differentiation of the
Drosophila retina. The extracellular signals that control these patterns have been identified …

The analysis of consequences resulting after experimental elimination of gene function has
been and will continue to be an extremely successful strategy in biological research …

Regulated changes in the cell cycle underlie many aspects of growth and differentiation.
Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized …