A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Many candidate biomarkers of human ageing have been proposed in the scientific literature
but in all cases their variability in cross-sectional studies is considerable, and therefore no …

Widespread aging at the population level is a recent phenomenon that emerged in affluent
societies. Inflammation is necessary to cope with damaging agents and is crucial for …

The geographic origins of populations can be identified by their maternally inherited
mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic …

Age-related macular degeneration (AMD) is the leading cause of vision loss in developed
countries. While linked to genetic polymorphisms in the complement pathway, there are …

Aim: In the present study, we investigated whether global DNA methylation levels are
affected by mitochondrial DNA (mtDNA) variants, which are known to modulate …

mtDNA is transmitted through the maternal line and its sequence variability, which is
population specific, is assumed to be phenotypically neutral. However, several studies have …

Oxidative stress is both the cause and consequence of impaired functional homeostasis
characterizing human aging. The worsening efficiency of stress response with age …

Autism spectrum disorder (ASD) as defined by the revised Diagnostic and Statistical Manual
of Mental Disorders: DSM IVTR criteria (American Psychiatric Association [2000] …

Leber's hereditary optic neuropathy is a maternally inherited optic atrophy caused by
mitochondrial DNA point mutations. Previous epidemiological studies have shown that …