Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …

Mature B lymphocytes (B cells) recognize antigens using their B cell receptor (BCR) and are
activated to become antibody-producing cells. In addition, and integral to the development of …

Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and
control tumor growth. However, it remains difficult to predict the antigens that will be …

Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5
million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 …

Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely
used to assess the binding of peptides to MHC proteins, particularly within the structural …

Infectious diseases are a burden for aquaculture. Antigen processing and presentation
(APP) to the immune effector cells that fight pathogens is key in the adaptive immune …

Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold
standard for acute and maintenance therapies. The therapeutic response to Li in BD is …

Neutrophils are the most abundant cells of the immune system and key in combating
infections through phagocytosis, reactive oxygen species, neutrophil extracellular traps, and …

Background A recent publication suggested molecular mimicry of a nucleoprotein (NP)
sequence from A/Puerto Rico/8/1934 (PR8) strain, the backbone used in the construction of …

Largemouth bass ranavirus (LMBV) is highly contagious and lethal to largemouth bass,
causing significant economic losses to the aquaculture industry. Oral vaccination is …