Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Prenatal and postnatal myogenesis share many cellular and molecular aspects. Myogenic
regulatory factors are basic Helix-Loop-Helix transcription factors that indispensably …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4
have critical roles in skeletal muscle development. Together with the Mef2 proteins and E …

The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as
such, is a model system in developmental biology for studying how a single initiating event …

The injury of adult skeletal muscle initiates series of well‐coordinated events that lead to the
efficient repair of the damaged tissue. Any disturbances during muscle myolysis or …

Introduction 3. Development and determination of the myogenic lineage 3.1. Somitogenesis:
formation of epaxial versus hypaxial musculature 3.2. The myogenic regulatory factors 3.2 …

Muscle satellite cells are responsible for the postnatal growth and robust regeneration
capacity of adult skeletal muscle. A subset of satellite cells purified from adult skeletal …

Skeletal muscle development, nutrient uptake, and nutrient utilization is largely coordinated
by growth hormone (GH) and its downstream effectors, in particular, IGF-1. However, it is not …

In skeletal myogenesis, the transcription factor MyoD activates distinct transcriptional
programs in progenitors compared to terminally differentiated cells. Using ChIP-Seq and …