Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

Malignant tumors are a major cause of death, and their incidence is increasing worldwide.
Although the survival rate for some cancers has improved, treatments for other malignant …

Alzheimer's disease (AD) is the most common neurodegenerative disease. The
accumulation of amyloid beta (Aβ) is the main pathology of AD. Metformin, a well‐known …

Objective: Monitoring the result of miR 409 3p and its response to tumor proliferation and its
mechanism of action on some types of lung cancer in vitro (A549 cell line). Methods: Two …

Pulmonary fibrosis (PF) is a progressive and devastating lung disease of unknown etiology,
excessive fibroblast proliferation serves as a key event to promote PF. Transcription factor …

Background Recent studies have shown that the classic hypoglycemic drug metformin
inhibits tumor growth; however, the underlying mechanism remains unclear. We previously …

Simple Summary The potential effects of metformin in terms of cancer prevention and
therapy have been widely studied, and a number of studies have indicated its potential role …

Метформин является противодиабетическим препаратом первой линии для лечения
сахарного диабета 2 типа (СД2); его молекулярной мишенью является АМФ …

Insulin resistance and hyperinsulinemia play a key role in type 1 endometrial cancer
pathogenesis. Most of these cancers develop on a background of overweight or type 2 …

Glioblastoma is the most common malignant tumor in the central nervous system. The
general transcription factor IIE subunit beta (GTF2E2) is crucial for physiological and …