Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic
cells′ life. Up to the 1990s of the past century, ROS have been solely considered as toxic …

Abstract Background Satellite cells (SCs) are critical to skeletal muscle regeneration.
Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is …

Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of
muscular mass and the contractile capacity of the skeletal muscle as a consequence of …

Skeletal muscle health is dependent on the optimal function of its mitochondria. With
advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part …

Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging …

Sarcopenia, the loss of muscle mass and function, is a common feature of aging and impacts
on individual health and quality of life. Several cellular mechanisms have been involved in …

As a systemic syndrome characterized by age-associated degenerative skeletal muscle
atrophy, sarcopenia leads to a risk of adverse outcomes in the elderly. Age-related iron …

Accelerated apoptosis in skeletal muscle is increasingly recognized as a potential
mechanism contributing to the development of sarcopenia of aging and disuse muscle …

Background Iron deficiency or overload may contribute to complications associated with
diseases, but the link between iron status and skeletal muscle disorder is poorly understood …