Lung cancer is the second most prevalent cancer and the leading cause of cancer‐related
death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and …

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …

DNA is often referred to as the “molecule of life” since it contains the genetic blueprint for all
forms of life on this planet. The core building blocks composing DNA are deoxynucleotides …

Amino acid metabolism has been actively investigated as a potential target for antitumor
therapy, but how it may alter the response to genotoxic chemotherapy remains largely …

Opinion Statement Compared to other types of lung cancer, small cell lung cancer (SCLC)
exhibits aggressive characteristics that promote drug resistance. Despite platinum-etoposide …

Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established
protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle …

Alterations of bases in DNA constitute a major source of genomic instability. It is believed
that base alterations trigger base excision repair (BER), generating DNA repair …

Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires
cross-resistance after relapse. This transformation is nearly inevitable in patients but has …

Aims Glioblastoma multiforme (GBM) is the most aggressive and mortal primary glioma in
adults. Temozolomide (TMZ) is a first-line clinical chemotherapeutic drug. However, TMZ …

Antibody–drug conjugates (ADCs) have become an important class of anticancer drugs in
solid tumors including drug-resistant gynecologic malignancies. TROP2 is a cell surface …