Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
An overview on the antimalarial activity of 1, 2, 4‐trioxanes, 1, 2, 4‐trioxolanes and 1, 2, 4, 5‐tetraoxanes
M Shukla, K Rathi, M Hassam… - Medicinal Research …, 2024 - Wiley Online Library
The demand for novel, fast‐acting, and effective antimalarial medications is increasing
exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading …
exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading …
[HTML][HTML] Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through …
Severe acute respiratory syndrome coronavirus disease (SARS-CoV-2) induced coronavirus
disease 2019 (COVID-19) pandemic is the present worldwide health emergency. The global …
disease 2019 (COVID-19) pandemic is the present worldwide health emergency. The global …
[HTML][HTML] Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness …
In view of the potential of traditional plant-based remedies (or phytomedicines) in the
management of COVID-19, the present investigation was aimed at finding novel anti-SARS …
management of COVID-19, the present investigation was aimed at finding novel anti-SARS …
In silico screening of phytopolyphenolics for the identification of bioactive compounds as novel protease inhibitors effective against SARS-CoV-2
M Rudrapal, AR Issahaku, C Agoni… - Journal of …, 2022 - Taylor & Francis
Due to the unavailability specific drugs or vaccines (FDA approved) that can cure COVID-19,
the development of potent antiviral drug candidates/therapeutic molecules against COVID …
the development of potent antiviral drug candidates/therapeutic molecules against COVID …
Seven metal-based bi-dentate NO azocoumarine complexes: Synthesis, physicochemical properties, DFT calculations, drug-likeness, in vitro antimicrobial screening …
A Abdou, HM Mostafa, AMM Abdel-Mawgoud - Inorganica Chimica Acta, 2022 - Elsevier
Abstract Herein, new Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) complexes based
on azocoumarin ligand, 2-[(E)-(2-oxo-2H-chromen-6-yl) diazenyl]-1-phenylbutane-1, 3 …
on azocoumarin ligand, 2-[(E)-(2-oxo-2H-chromen-6-yl) diazenyl]-1-phenylbutane-1, 3 …
[HTML][HTML] Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1, 4, 5-trisubstituted 1, 2, 3-triazoles …
Malaria is a killer disease caused by Plasmodium falciparum and is responsible for over a
million death annually. Chloroquine, quinine, pyrimethamine, proguanil, artemisinin …
million death annually. Chloroquine, quinine, pyrimethamine, proguanil, artemisinin …
Utilizing Andrographis paniculata leaves and roots by effective usage of the bioactive andrographolide and its nanodelivery: Investigation of antikindling and …
R Baru Venkata, DSNBK Prasanth, PK Pasala… - Frontiers in …, 2023 - frontiersin.org
To valorise the bioactive constituents abundant in leaves and other parts of medicinal plants
with the objective to minimize the plant-based wastes, this study was undertaken. The main …
with the objective to minimize the plant-based wastes, this study was undertaken. The main …
Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo [d] imidazole derivatives as potential EGFR inhibitors
CE Theodore, G Sivaiah, SBB Prasad… - Journal of Molecular …, 2023 - Elsevier
Here, we present the design, synthesis, and evaluation of a new series of 1H-benzo [d]
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
[HTML][HTML] Design, molecular docking, drug-likeness, and molecular dynamics studies of 1, 2, 4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) …
S Ghosh, D Chetia, N Gogoi, M Rudrapal - Biotechnologia, 2021 - ncbi.nlm.nih.gov
Despite significant progress made in drug discovery and development over the past few
decades, malaria remains a life-threatening infectious disease across the globe. Because of …
decades, malaria remains a life-threatening infectious disease across the globe. Because of …