Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …

Homology—a similar trait shared by different species and derived from common ancestry,
such as a seal's fin and a bird's wing—is one of the most fundamental yet challenging …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

The suggestion that the native state of many proteins is intrinsically disordered (or, as
originally termed, unstructured) is now integral to our general view of protein structure and …

This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …

Traditionally, protein–protein interactions were thought to be mediated by large, structured
domains. However, it has become clear that the interactome comprises a wide range of …