Inside job: Staphylococcus aureus host-pathogen interactions
J Horn, K Stelzner, T Rudel, M Fraunholz - International Journal of Medical …, 2018 - Elsevier
Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of
diseases. Recent research established that once phagocytosed by neutrophils and …
diseases. Recent research established that once phagocytosed by neutrophils and …
Thinking outside the box—novel antibacterials to tackle the resistance crisis
M Lakemeyer, W Zhao, FA Mandl… - Angewandte Chemie …, 2018 - Wiley Online Library
The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …
superbugs” appeared in the news. While reasons for this resistance development are easily …
Staphylococcal response to oxidative stress
R Gaupp, N Ledala, GA Somerville - Frontiers in cellular and infection …, 2012 - frontiersin.org
Staphylococci are a versatile genus of bacteria that are capable of causing acute and
chronic infections in diverse host species. The success of staphylococci as pathogens is due …
chronic infections in diverse host species. The success of staphylococci as pathogens is due …
Staphylococcus aureus aggregation and coagulation mechanisms, and their function in host–pathogen interactions
The human commensal bacterium Staphylococcus aureus can cause a wide range of
infections ranging from skin and soft tissue infections to invasive diseases like septicemia …
infections ranging from skin and soft tissue infections to invasive diseases like septicemia …
The Staphylococcus aureus ArlRS two‐component system regulates virulence factor expression through MgrA
Summary The Gram‐positive bacterium, Staphylococcus aureus, is a versatile pathogen that
can sense and adapt to a wide variety of environments within the human host, in part …
can sense and adapt to a wide variety of environments within the human host, in part …
Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective
CP Gordon, P Williams, WC Chan - Journal of medicinal chemistry, 2013 - ACS Publications
Virulence gene expression in Staphylococcus aureus is tightly regulated by intricate
networks of transcriptional regulators and two-component signal transduction systems …
networks of transcriptional regulators and two-component signal transduction systems …
Salicylic acid stabilizes Staphylococcus aureus biofilm by impairing the agr quorum-sensing system
C Dotto, A Lombarte Serrat, M Ledesma, C Vay… - Scientific Reports, 2021 - nature.com
Salicylic acid (SAL) has recently been shown to induce biofilm formation in Staphylococcus
aureus and to affect the expression of virulence factors. This study was aimed to investigate …
aureus and to affect the expression of virulence factors. This study was aimed to investigate …
Coupling a virulence-targeting moiety with Ru-based AMP mimics efficiently improved its anti-infective potency and therapeutic index
J Wang, Y Song, Z Huang, W Lin, G Yu… - Journal of Medicinal …, 2023 - ACS Publications
The surge of antibiotic resistance in Staphylococcus aureus calls for novel drugs that attack
new targets. Developing antimicrobial peptides (AMPs) or antivirulence agents (AvAs) is a …
new targets. Developing antimicrobial peptides (AMPs) or antivirulence agents (AvAs) is a …
Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS–MgrA signaling cascade
JM Kwiecinski, HA Crosby, C Valotteau… - PLoS …, 2019 - journals.plos.org
Staphylococcus aureus is a leading cause of endovascular infections. This bacterial
pathogen uses a diverse array of surface adhesins to clump in blood and adhere to vessel …
pathogen uses a diverse array of surface adhesins to clump in blood and adhere to vessel …
Chemical and Biological Aspects of Nutritional Immunity—Perspectives for New Anti‐Infectives that Target Iron Uptake Systems
U Bilitewski, JAV Blodgett… - Angewandte Chemie …, 2017 - Wiley Online Library
Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of
essential metal ions, in particular iron, which leads to “nutritional immunity”. However …
essential metal ions, in particular iron, which leads to “nutritional immunity”. However …