Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …

Apelin, an endogenous ligand for the G protein–coupled receptor (APJ), is widely distributed
within the central nervous system and diverse organs in human and animals. Recent studies …

Apelin is an endogenous ligand of G protein-coupled receptor APJ. It is extensively
expressed in many tissues such as heart, liver, and kidney, especially in lung tissue. A …

The apelinergic pathway has been generating increasing interest in the past few years for its
potential as a therapeutic target in several conditions associated with the cardiovascular and …

Apelin, a (neuro) vasoactive peptide, plays a prominent role in controlling body fluid
homeostasis and cardiovascular functions. Experimental data performed in rodents have …

Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many
studies have shown that the apelin/APJ system has neuroprotective properties, such as anti …

APJ is a G protein‐coupled receptor and its endogenous ligand is apelin. Studies have
shown that apelin/APJ system is widely distributed in the body, especially highly expressed …

Heart failure (HF) remains a grievous illness with poor prognosis even with optimal care.
The apelin receptor (APJ) counteracts the pressor effect of angiotensin II, attenuates …

Side-chain-constrained amino acids are useful tools to modulate the biological properties of
peptides. In this study, we applied side-chain constraints to apelin-13 (Ape13) by …

Cardiovascular diseases are the leading cause of death worldwide. The renin-angiotensin-
aldosterone system is one of the major regulators of cardiovascular homeostasis and the …