Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
C Johannessen Landmark… - Expert opinion on …, 2020 - Taylor & Francis
ABSTRACT Introduction: Antiepileptic drugs (AEDs) are the cornerstone of treatment of
patients with epilepsy, and there are presently 27 licensed AEDs making AEDs among the …
patients with epilepsy, and there are presently 27 licensed AEDs making AEDs among the …
[HTML][HTML] An updated overview on therapeutic drug monitoring of recent antiepileptic drugs
Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs),
therapeutic drug monitoring (TDM) can make a significant contribution to the field of …
therapeutic drug monitoring (TDM) can make a significant contribution to the field of …
Seizures and gliomas—towards a single therapeutic approach
G Huberfeld, CJ Vecht - Nature Reviews Neurology, 2016 - nature.com
Epilepsy often develops in patients with glioma, and the two conditions share common
pathogenic mechanisms. Altered expression of glutamate transporters, including the cystine …
pathogenic mechanisms. Altered expression of glutamate transporters, including the cystine …
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines
Background and objective Laboratories sometimes use different reference ranges for the
same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may …
same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may …
Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update
D Italiano, E Perucca - Clinical pharmacokinetics, 2013 - Springer
Epilepsies occur across the entire age range, and their incidence peaks in the first years of
life and in the elderly. Therefore, antiepileptic drugs (AEDs) are commonly used at the …
life and in the elderly. Therefore, antiepileptic drugs (AEDs) are commonly used at the …
Dosing strategies for antiepileptic drugs: from a standard dose for all to individualised treatment by implementation of therapeutic drug monitoring
CJ Landmark, SI Johannessen, T Tomson - Epileptic Disorders, 2016 - Wiley Online Library
This review focuses on the evolution of approaches to dosing of antiepileptic drugs (AEDs)
in clinical practice through history. There has been a shift in the view of treatment of …
in clinical practice through history. There has been a shift in the view of treatment of …
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
Despite being one of the most commonly prescribed antiepileptic drugs, levetiracetam is
marketed in oral and intravenous dosage forms, which are associated to drug-drug …
marketed in oral and intravenous dosage forms, which are associated to drug-drug …
Therapeutic drug monitoring of levetiracetam in select populations
D Jarvie, SH Mahmoud - Journal of Pharmacy & …, 2018 - journals.library.ualberta.ca
Purpose: Levetiracetam (LEV) is a broad spectrum antiepileptic drug (AED) that has a more
favorable side effect profile compared to older AEDs. Therapeutic drug monitoring (TDM) of …
favorable side effect profile compared to older AEDs. Therapeutic drug monitoring (TDM) of …
[HTML][HTML] Review on the relevance of therapeutic drug monitoring of levetiracetam
J Sourbron, HY Chan, EA Wammes-van der Heijden… - Seizure, 2018 - Elsevier
Abstract Therapeutic Drug Monitoring (TDM) of anti-epileptic drugs (AEDs) is not routinely
performed, although this can guide the dosage regimen to achieve greater efficacy and …
performed, although this can guide the dosage regimen to achieve greater efficacy and …
Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations
C Shen, W Shao, W Wang, H Sun… - CPT …, 2023 - Wiley Online Library
Levetiracetam (LEV) is an anti‐epileptic drug approved for use in various populations. The
pharmacokinetic (PK) behavior of LEV may be altered in the elderly and patients with renal …
pharmacokinetic (PK) behavior of LEV may be altered in the elderly and patients with renal …