Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer

TJ Morrison, MV Jackson, EK Cunningham… - American journal of …, 2017 - atsjournals.org
Rationale: Acute respiratory distress syndrome (ARDS) remains a major cause of respiratory
failure in critically ill patients. Mesenchymal stromal cells (MSCs) are a promising candidate …

Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in …

MV Jackson, TJ Morrison, DF Doherty, DF McAuley… - Stem …, 2016 - academic.oup.com
Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in
preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The …

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

JG Wilson, KD Liu, H Zhuo, L Caballero… - The Lancet …, 2015 - thelancet.com
Background No effective pharmacotherapy for acute respiratory distress syndrome (ARDS)
exists, and mortality remains high. Preclinical studies support the efficacy of mesenchymal …

The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia

J Park, S Kim, H Lim, A Liu, S Hu, JH Lee, H Zhuo… - Thorax, 2019 - thorax.bmj.com
Background We previously reported that microvesicles (MVs) released by human
mesenchymal stem cells (MSC) were as effective as the cells themselves in both …

Clinical applications of mesenchymal stem cells

S Wang, X Qu, RC Zhao - Journal of hematology & oncology, 2012 - Springer
Mesenchymal stem cells (MSC) have generated a great amount of enthusiasm over the past
decade as a novel therapeutic paradigm for a variety of diseases. Currently, MSC based …

The potential of mesenchymal stem cell therapy for chronic lung disease

FF Cruz, PRM Rocco - Expert Review of Respiratory Medicine, 2020 - Taylor & Francis
Introduction: Mesenchymal stem/stromal cells (MSCs) have been shown to improve lung
function and survival in chronic inflammatory lung diseases, including asthma, chronic …

Fifty Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value

JG Laffey, MA Matthay - American journal of respiratory and critical …, 2017 - atsjournals.org
On the basis of several preclinical studies, cell-based therapy has emerged as a potential
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …