Bidirectional microglia–neuron communication in health and disease

Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

The biphasic function of microglia in ischemic stroke

Y Ma, J Wang, Y Wang, GY Yang - Progress in neurobiology, 2017 - Elsevier
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

DP Schafer, EK Lehrman, AG Kautzman, R Koyama… - Neuron, 2012 - cell.com
Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …

Physiology of microglia

H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Priming of microglia with IFN‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects

J Zhang, H He, Y Qiao, T Zhou, H He, S Yi, L Zhang… - Glia, 2020 - Wiley Online Library
Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation

DJ Loane, A Kumar, BA Stoica… - … of Neuropathology & …, 2014 - academic.oup.com
Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is …

[HTML][HTML] Microglial activation and chronic neurodegeneration

ME Lull, ML Block - Neurotherapeutics, 2010 - Elsevier
Microglia, the resident innate immune cells in the brain, have long been implicated in the
pathology of neurodegenerative diseases. Accumulating evidence points to activated …

The adverse effects of air pollution on the nervous system

S Genc, Z Zadeoglulari, SH Fuss… - Journal of toxicology, 2012 - Wiley Online Library
Exposure to ambient air pollution is a serious and common public health concern associated
with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air …

Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children

S Vujosevic, MM Parra, ME Hartnett, L O'Toole, A Nuzzi… - Eye, 2023 - nature.com
The retina and the optic nerve are considered extensions of the central nervous system
(CNS) and thus can serve as the window for evaluation of CNS disorders. Spectral domain …