Macrophage phagocytosis after spinal cord injury: when friends become foes

J Van Broeckhoven, D Sommer, D Dooley, S Hendrix… - Brain, 2021 - academic.oup.com
After spinal cord injury, macrophages can exert either beneficial or detrimental effects
depending on their phenotype. Aside from their critical role in inflammatory responses …

Macrophagic and microglial complexity after neuronal injury

F Mesquida-Veny, JA Del Río, A Hervera - Progress in neurobiology, 2021 - Elsevier
Central nervous system (CNS) injuries do not heal properly in contrast to normal tissue
repair, in which functional recovery typically occurs. The reason for this dichotomy in wound …

Berberine-loaded MSC-derived sEVs encapsulated in injectable GelMA hydrogel for spinal cord injury repair

H Wang, Q Tang, Y Lu, C Chen, Y Zhao, T Xu… - International Journal of …, 2023 - Elsevier
After spinal cord injury (SCI), local inflammatory response and fibrous scar formation
severely hinder nerve regeneration. Berberine (Ber) has a powerful regulatory effect on the …

In Situ Cross-Linkable Hyaluronic–Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury

F Sorouri, P Hosseini, M Sharifzadeh… - … Applied Materials & …, 2023 - ACS Publications
Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar
formation, leading to the inhibition of new axon growth and impaired regeneration …

Human placental mesenchymal stem cell-derived exosomes in combination with hyperbaric oxygen synergistically promote recovery after spinal cord injury in rats

H Cheshmi, H Mohammadi, M Akbari, D Nasiry… - Neurotoxicity …, 2023 - Springer
Spinal cord injury (SCI) is a critical medical condition during which sensorimotor function is
lost. Current treatments are still unable to effectively improve these conditions, so it is …

Regenerative effects of exosomes-derived MSCs: an overview on spinal cord injury experimental studies

G Schepici, S Silvestro, E Mazzon - Biomedicines, 2023 - mdpi.com
Spinal cord injury (SCI) is a devastating condition usually induced by the initial mechanical
insult that can lead to permanent motor and sensory deficits. At present, researchers are …

The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation

DJ Hellenbrand, CM Quinn, ZJ Piper… - Neural Regeneration …, 2024 - journals.lww.com
After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates
the injury and leads to further neural degeneration. Therefore, a major aim of current …

Challenges of delirium management in patients with traumatic brain injury: from pathophysiology to clinical practice

SW Roberson, MB Patel, W Dabrowski… - Current …, 2021 - benthamdirect.com
Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous
system (CNS), starting with the primary pathology of the inciting trauma and subsequent …

Thermos-responsive hydrogel system encapsulated engineered exosomes attenuate inflammation and oxidative damage in acute spinal cord injury

Y Xiao, X Hu, P Jiang, Z Qi - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Introduction: Spinal cord injury (SCI) is a serious and disabling condition, and the
effectiveness of conventional treatment is limited, such as supportive treatment and …

Biomaterial-mediated factor delivery for spinal cord injury treatment

F Pinelli, F Pizzetti, V Veneruso, E Petillo, M Raghunath… - Biomedicines, 2022 - mdpi.com
Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage
to the spinal cord and associated tissues during an acute traumatic event. However, the …