Many bacterial cellular processes interact intimately with the chromosome. Such interplay is
the major driving force of genome structure or organization. Interactions take place at …

Data obtained with advanced imaging techniques, chromosome conformation capture
methods, bioinformatics and molecular genetics, together with insights from polymer physics …

Operons (clusters of co-regulated genes with related functions) are common features of
bacterial genomes. More recently, functional gene clustering has been reported in …

A fundamental principle of exponential bacterial growth is that no more ribosomes are
produced than are necessary to support the balance between nutrient availability and …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

What are the forces that shape the structure of prokaryotic genomes: the order of genes, their
proximity, and their orientation? Coregulation and coordinated horizontal gene transfer are …

Gene translocations play an important role in the plasticity and evolution of bacterial
genomes. In this study, we investigated the impact on gene regulation of three genome …

We consider the first-passage problem for N identical independent particles that are initially
released uniformly in a finite domain Ω and then diffuse toward a reactive area Γ, which can …

Recent studies have revealed that the bacterial nucleoid is a dynamic entity that alters its
overall structure in response to changes in both growth rate and growth phase. These …

Computational scientists have developed algorithms inspired by natural evolution for at least
50 years. These algorithms solve optimization and design problems by building solutions …