[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF

S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

Small molecule inhibitors targeting the cancers

GH Liu, T Chen, X Zhang, XL Ma, HS Shi - MedComm, 2022 - Wiley Online Library
Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

[HTML][HTML] Integrated proteogenomic characterization of medullary thyroid carcinoma

X Shi, Y Sun, C Shen, Y Zhang, R Shi, F Zhang, T Liao… - Cell Discovery, 2022 - nature.com
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy derived from
parafollicular cells (C cells) of the thyroid. Here we presented a comprehensive multi-omics …

A roadmap for the early detection and diagnosis of cancer

D Crosby, N Lyons, E Greenwood, S Harrison… - The Lancet …, 2020 - thelancet.com
If we are to beat cancer, early detection and diagnosis are arguably the most effective
means we have at our disposal. Progress during the past 40 years has transformed the …

Lenvatinib in patients with advanced grade 1/2 pancreatic and gastrointestinal neuroendocrine tumors: results of the phase II TALENT trial (GETNE1509)

J Capdevila, N Fazio, C Lopez, A Teulé… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Approved systemic therapies for advanced gastroenteropancreatic
neuroendocrine tumors (GEP-NETs) have shown limited capacity to reduce tumor burden …

DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms

J Yao, E Bergsland, R Aggarwal, A Aparicio… - The …, 2022 - academic.oup.com
Introduction Neuroendocrine neoplasms (NEN) are heterogeneous malignancies that can
arise at almost any anatomical site and are classified as biologically distinct well …

[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine …

B Kos-Kudła, W Foltyn, A Malczewska… - Endokrynologia …, 2022 - journals.viamedica.pl
Continuous progress in the diagnostics and treatment of neuroendocrine neoplasms
(NENs), the emerging results of new clinical trials, and the new guidelines issued by medical …

Neuroendocrine tumors and peptide receptor radionuclide therapy: when is the right time?

TA Hope, M Pavel, EK Bergsland - Journal of Clinical Oncology, 2022 - ascopubs.org
Since its approval in 2018 by the US Food and Drug Administration, peptide receptor
radionuclide therapy (PRRT) has become a mainstay in the treatment of neuroendocrine …

[HTML][HTML] Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma

A Ooki, H Osumi, K Fukuda, K Yamaguchi - Cancer and Metastasis …, 2023 - Springer
Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …