Chemical approaches to cryopreservation
KA Murray, MI Gibson - Nature Reviews Chemistry, 2022 - nature.com
Cryopreservation of cells and biologics underpins all biomedical research from routine
sample storage to emerging cell-based therapies, as well as ensuring cell banks provide …
sample storage to emerging cell-based therapies, as well as ensuring cell banks provide …
Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials
D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …
implants and is a major obstacle to the development of implantable biomaterials and …
An electrogenetic interface to program mammalian gene expression by direct current
J Huang, S Xue, P Buchmann, AP Teixeira… - Nature …, 2023 - nature.com
Wearable electronic devices are playing a rapidly expanding role in the acquisition of
individuals' health data for personalized medical interventions; however, wearables cannot …
individuals' health data for personalized medical interventions; however, wearables cannot …
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques
The transplantation of pancreatic islet cells could restore glycaemic control in patients with
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
The transplantation of glucose-responsive, insulin-producing cells offers the potential for
restoring glycemic control in individuals with diabetes. Pancreas transplantation and the …
restoring glycemic control in individuals with diabetes. Pancreas transplantation and the …
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
The foreign body response is an immune-mediated reaction that can lead to the failure of
implanted medical devices and discomfort for the recipient,,,,,. There is a critical need for …
implanted medical devices and discomfort for the recipient,,,,,. There is a critical need for …
Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
Host recognition and immune-mediated foreign body response to biomaterials can
compromise the performance of implanted medical devices. To identify key cell and cytokine …
compromise the performance of implanted medical devices. To identify key cell and cytokine …
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and
can compromise the function of implants or cause complications. For example, in cell …
can compromise the function of implants or cause complications. For example, in cell …
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice
K Krawczyk, S Xue, P Buchmann, G Charpin-El-Hamri… - Science, 2020 - science.org
Sophisticated devices for remote-controlled medical interventions require an electrogenetic
interface that uses digital electronic input to directly program cellular behavior. We present a …
interface that uses digital electronic input to directly program cellular behavior. We present a …
Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate
Screening implantable biomaterials for antifibrotic properties is constrained by the need for
in vivo testing. Here we show that the throughput of in vivo screening can be increased by …
in vivo testing. Here we show that the throughput of in vivo screening can be increased by …