Chemical approaches to cryopreservation

KA Murray, MI Gibson - Nature Reviews Chemistry, 2022 - nature.com
Cryopreservation of cells and biologics underpins all biomedical research from routine
sample storage to emerging cell-based therapies, as well as ensuring cell banks provide …

Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials

D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …

An electrogenetic interface to program mammalian gene expression by direct current

J Huang, S Xue, P Buchmann, AP Teixeira… - Nature …, 2023 - nature.com
Wearable electronic devices are playing a rapidly expanding role in the acquisition of
individuals' health data for personalized medical interventions; however, wearables cannot …

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques

MA Bochenek, O Veiseh, AJ Vegas… - Nature biomedical …, 2018 - nature.com
The transplantation of pancreatic islet cells could restore glycaemic control in patients with
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

AJ Vegas, O Veiseh, M Gürtler, JR Millman… - Nature medicine, 2016 - nature.com
The transplantation of glucose-responsive, insulin-producing cells offers the potential for
restoring glycemic control in individuals with diabetes. Pancreas transplantation and the …

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

AJ Vegas, O Veiseh, JC Doloff, M Ma, HH Tam… - Nature …, 2016 - nature.com
The foreign body response is an immune-mediated reaction that can lead to the failure of
implanted medical devices and discomfort for the recipient,,,,,. There is a critical need for …

Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates

JC Doloff, O Veiseh, AJ Vegas, HH Tam, S Farah… - Nature materials, 2017 - nature.com
Host recognition and immune-mediated foreign body response to biomaterials can
compromise the performance of implanted medical devices. To identify key cell and cytokine …

Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

Q Liu, A Chiu, LH Wang, D An, M Zhong… - Nature …, 2019 - nature.com
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and
can compromise the function of implants or cause complications. For example, in cell …

Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice

K Krawczyk, S Xue, P Buchmann, G Charpin-El-Hamri… - Science, 2020 - science.org
Sophisticated devices for remote-controlled medical interventions require an electrogenetic
interface that uses digital electronic input to directly program cellular behavior. We present a …

Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate

S Mukherjee, B Kim, LY Cheng, MD Doerfert… - Nature Biomedical …, 2023 - nature.com
Screening implantable biomaterials for antifibrotic properties is constrained by the need for
in vivo testing. Here we show that the throughput of in vivo screening can be increased by …