Bacillus subtilis is a soil-dwelling, spore-forming Gram-positive bacterium capable of cell
differentiation. For decades, B. subtilis has been used as a model organism to study …

Protein modifications not only affect protein homeostasis but can also establish new cellular
protein functions and are important components of complex cellular signal sensing and …

Reversible protein phosphorylation on serine, threonine, and tyrosine (Ser/Thr/Tyr) residues
plays a critical role in regulation of vital processes in the cell. Despite of considerable …

Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal
kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the …

Synechocystis sp. PCC 6803 (hereafter Synechocystis) is a model cyanobacterium and has
been used extensively for studies concerned with photosynthesis and environmental …

The Gram-positive soil bacterium Bacillus subtilis is able to choose between motile and
sessile lifestyles. The sessile way of life, also referred to as biofilm, depends on the …

Understanding phosphorylation-mediated regulation of metabolic enzymes, pathways, and
cell phenotypes under metabolic shifts represents a major challenge. The kinases …

Reversible phosphorylation of bacterial transcriptional regulators (TRs) belonging to the
family of two-component systems (TCSs) is a well-established mechanism for regulating …

Divergent genes in Staphylococcus aureus USA300 encode the efflux pump FarE and TetR
family regulator FarR, which confer resistance to antimicrobial unsaturated fatty acids. To …

Protein phosphorylation is a universal mechanism regulating a wide range of cellular
responses across all domains of life. The antagonistic activities of kinases and …