The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …

Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are
made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars …

In recent years, significant effort has gone into making synthetic oligomers that can attain
well-defined conformations analogous to the folding of biomolecules. The diversity of the …

Heparin is a vital biomolecule in widespread clinical use as an anti-coagulant. Heparin
sensors have potential applications in the bedside detection of heparin levels in human …

Heparins are widely used anticoagulants for surgical procedures and extracorporeal
therapies. However, all of them have bleeding risks. Protamine sulfate, the only clinically …

Naturally occurring peptides serve important functions as enzyme inhibitors, hormones,
neurotransmitters, and immunomodulators in many physiological processes including …

In a search for small molecule antagonists of heparan sulfate, we examined the activity of bis-
2-methyl-4-amino-quinolyl-6-carbamide, also known as surfen. Fluorescence-based …

The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–
protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be …

We report the simple synthesis and full investigation of a novel heparin binding dye, mallard
blue, an arginine-functionalized thionine. This dye binds heparin in highly competitive …