The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure
in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis …

Neutrophil extracellular traps (NETs) assist pathogen clearance, while excessive NETs
formation is associated with exacerbated inflammatory responses and tissue injury in acute …

Sepsis-associated encephalopathy (SAE) manifested clinically in acute and long-term
cognitive impairments and associated with increased morbidity and mortality worldwide. The …

Sepsis-associated acute kidney injury (SA-AKI) is common in patients with severe sepsis,
and has a high incidence rate and high mortality rate in ICU patients. Most patients progress …

Background Systemic inflammation is a whole body reaction having an infection-positive (ie,
sepsis) or infection-negative origin. It is important to distinguish between these two …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) undergoes the process of
pathological event including lung tissue dysfunction, pulmonary edema, and inflammation in …

Sepsis‑induced cardiomyopathy (SIC) is a complication of severe sepsis and septic shock
characterized by an invertible myocardial depression. This study sought to explore the …

Inflammation is a central feature of an effective immune response, which functions to
eliminate pathogens and other foreign material, and promote recovery; however …