Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

The advent of single-cell sequencing started a new era of transcriptomic and genomic
research, advancing our knowledge of the cellular heterogeneity and dynamics. Cell type …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

The mitochondrial genome (mtDNA) encodes essential machinery for oxidative
phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically …

Neuropsychiatric manifestations are common in both the acute and post-acute phase of
SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly …

Here we describe single-cell corrected long-read sequencing (scCOLOR-seq), which
enables error correction of barcode and unique molecular identifier oligonucleotide …

The BCL2 inhibitor venetoclax has recently emerged as an important component of acute
myeloid leukemia (AML) therapy. Notably, use of this agent has revealed a previously …

Patients suffering from Coronavirus disease 2019 (COVID-19) can develop neurological
sequelae, such as headache and neuroinflammatory or cerebrovascular disease. These …

Pioneer transcription factors are thought to play pivotal roles in developmental processes by
binding nucleosomal DNA to activate gene expression, though mechanisms through which …

Neurodegenerative diseases affect millions of people worldwide and there are currently no
cures. Two types of common neurodegenerative diseases are Alzheimer's (AD) and …