Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid
peroxidation, which is characterized by mitochondrial morphological changes and has a …

CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …

Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its
function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the …

Metabolomics technologies enable the examination and identification of endogenous
biochemical reaction products, revealing information on the precise metabolic pathways and …

Metabolomics enables the profiling of large numbers of small molecules in cells, tissues and
biological fluids. These molecules, which include amino acids, carbohydrates, lipids …

Major depressive disorder (MDD) is a widespread and debilitating mental disorder.
However, there are no biomarkers available to aid in the diagnosis of this disorder. In this …

Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …

E2F transcription factors are implicated in diverse cellular functions. The founding member,
E2F‐1, is endowed with contradictory activities, being able to promote cell‐cycle …