Interstitial lung abnormalities: state of the art

A Hata, ML Schiebler, DA Lynch, H Hatabu - Radiology, 2021 - pubs.rsna.org
The clinical importance of interstitial lung abnormality (ILA) is increasingly recognized. In
July 2020, the Fleischner Society published a position paper about ILA. The purposes of this …

[HTML][HTML] Neutrophil elastase: From mechanisms to therapeutic potential

W Zeng, Y Song, R Wang, R He, T Wang - Journal of Pharmaceutical …, 2023 - Elsevier
Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is
involved in microbicidal activity. NE is an important factor promoting inflammation, has …

Radiobiology of the FLASH effect

AA Friedl, KM Prise, KT Butterworth… - Medical …, 2022 - Wiley Online Library
Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …

Dynamic circulating tumor DNA during chemoradiotherapy predicts clinical outcomes for locally advanced non-small cell lung cancer patients

Y Pan, JT Zhang, X Gao, ZY Chen, B Yan, PX Tan… - Cancer Cell, 2023 - cell.com
The value of circulating tumor DNA (ctDNA) during chemoradiotherapy (CRT) remains
unclear but is critical for detecting molecular residual disease (MRD). In this prospective …

Radiation-induced kidney toxicity: molecular and cellular pathogenesis

R Klaus, M Niyazi, B Lange-Sperandio - Radiation oncology, 2021 - Springer
Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical
setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation …

The role of macrophages in liver fibrosis: new therapeutic opportunities

E Binatti, A Gerussi, D Barisani, P Invernizzi - International journal of …, 2022 - mdpi.com
Chronic inflammation is the hallmark of fibrotic disorders and is characterized by the
activation of immune cells in the damaged tissues. Macrophages have emerged as central …

Induction of accelerated aging in a mouse model

N Cai, Y Wu, Y Huang - Cells, 2022 - mdpi.com
With the global increase of the elderly population, the improvement of the treatment for
various aging-related diseases and the extension of a healthy lifespan have become some …

Comparison of deep inspiration breath hold versus free breathing in radiotherapy for left sided breast cancer

Y Lu, D Yang, X Zhang, Y Teng, W Yuan… - Frontiers in …, 2022 - frontiersin.org
Objectives Modern breast cancer techniques, such as the deep inspiration breath-hold
(DIBH) technique has been applied for left-sided breast cancer. Whether the DIBH regimen …

Activation of the P62‐Keap1‐NRF2 Pathway Protects against Ferroptosis in Radiation‐Induced Lung Injury

X Li, J Chen, S Yuan, X Zhuang… - Oxidative medicine and …, 2022 - Wiley Online Library
Radiation‐induced lung injury (RILI) is one of the most common, serious, and dose‐limiting
toxicities of thoracic radiotherapy. A primary cause for this is the radiation‐induced cell …

[HTML][HTML] Long and short non-coding RNA and radiation response: a review

JM May, M Bylicky, S Chopra, CN Coleman… - Translational …, 2021 - Elsevier
Once thought of as arising from “junk DNA,” non-coding RNAs (ncRNAs) have emerged as
key molecules in cellular processes and response to stress. From diseases such as cancer …