Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies
BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …
research based on biologically accurate screening approaches. Since establishing the 2D in …
[HTML][HTML] The role of Alzheimer's disease risk genes in endolysosomal pathways
There is ample pathological and biological evidence for endo-lysosomal dysfunction in
Alzheimer's disease (AD) and emerging genetic studies repeatedly implicate endo …
Alzheimer's disease (AD) and emerging genetic studies repeatedly implicate endo …
Direct neuronal reprogramming: bridging the gap between basic science and clinical application
L Vasan, E Park, LA David, T Fleming… - Frontiers in Cell and …, 2021 - frontiersin.org
Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …
[HTML][HTML] The need for biological countermeasures to mitigate the risk of space radiation-induced carcinogenesis, cardiovascular disease, and central nervous system …
BJ Sishc, J Zawaski, J Saha, LS Carnell… - Life Sciences in Space …, 2022 - Elsevier
NASA's currently planned long-duration, deep space exploration missions outside of low
Earth orbit (LEO) will result in the exposure of astronauts to relatively high lifetime doses of …
Earth orbit (LEO) will result in the exposure of astronauts to relatively high lifetime doses of …
Replacing animal testing with stem cell-organoids: advantages and limitations
G Park, YA Rim, Y Sohn, Y Nam, JH Ju - Stem Cell Reviews and Reports, 2024 - Springer
Various groups including animal protection organizations, medical organizations, research
centers, and even federal agencies such as the US Food and Drug Administration, are …
centers, and even federal agencies such as the US Food and Drug Administration, are …
Modified ECM-based bioink for 3D printing of multi-scale vascular networks
The survival and function of tissues depend on appropriate vascularization. Blood vessels of
the tissues supply oxygen, and nutrients and remove waste and byproducts. Incorporating …
the tissues supply oxygen, and nutrients and remove waste and byproducts. Incorporating …
Vesicular glutamate release from feeder-freehiPSC-derived neurons
Human-induced pluripotent stem cells (hiPSCs) represent one of the main and powerful
tools for the in vitro modeling of neurological diseases. Standard hiPSC-based protocols …
tools for the in vitro modeling of neurological diseases. Standard hiPSC-based protocols …
A consolidated review on stem cell therapy for treatment and management of Alzheimer's disease
F Ahmad, P Sachdeva - Aging Medicine, 2022 - Wiley Online Library
Alzheimer's disease (AD) is one of the most common forms of dementia and affects around
50 million people around the globe. AD is diagnosed mainly through imaging techniques …
50 million people around the globe. AD is diagnosed mainly through imaging techniques …
Cerebral organoids as a new model for prion disease
The rapid development of induced pluripotent stem cell (iPSC) technology has considerably
expanded the range of human cell and tissue models available for investigators. IPSCs can …
expanded the range of human cell and tissue models available for investigators. IPSCs can …
Zika virus vertical transmission induces neuroinflammation and synapse impairment in brain cells derived from children born with Congenital Zika Syndrome
Zika virus (ZIKV) infection was first reported in 2015 in Brazil as causing microcephaly and
other developmental abnormalities in newborns, leading to the identification of Congenital …
other developmental abnormalities in newborns, leading to the identification of Congenital …