Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

Although the DNA double-strand break (DSB) is defined as a rupture in the double-stranded
DNA molecule that can occur without chemical modification in any of the constituent building …

Homologous recombination (HR) is essential for genome integrity. Recombination proteins
participate in tolerating DNA lesions that interfere with DNA replication, but can also …

The checkpoint kinase Rad53 is activated during replication stress to prevent fork collapse,
an essential but poorly understood process. Here we show that Rad53 couples leading-and …

Chromosome translocations are hallmark of cancer and of radiation-induced cell killing,
reflecting joining of incongruent DNA-ends that alter the genome. Translocation-formation …

In response to DNA replication stress, DNA replication checkpoint kinase Mec1
phosphorylates Mrc1, which in turn activates Rad53 to prevent the generation of deleterious …

The replication of eukaryote chromosomes slows down when DNA is damaged and the
proteins that work at the fork (the replisome) are known targets for the signaling pathways …

DNA replication stress threatens ordinary DNA synthesis. The evolutionarily conserved DNA
replication stress response pathway involves sensor kinase Mec1/ATR, adaptor protein …

In Saccharomyces cerevisiae, histone H3 lysine 56 acetylation (H3K56ac) occurs on all
newly synthesized histones H3 that are deposited behind DNA replication forks. H3K56ac …

The integrity of the genome relies on the maintenance of chromosomes, the structural
embodiment of the genetic material. Disruption of chromosome replication can lead to …