Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple
clinical conditions and may be associated with a variety of cardiovascular and respiratory …

Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF
cases, and its prevalence relative to HF with reduced EF continues to rise. In contrast to HF …

Heart failure is characterized by pathologic hemodynamic derangements, including elevated
cardiac filling pressures (“backward” failure), which may or may not coexist with reduced …

Background: Diagnosis of heart failure with preserved ejection fraction (HFpEF) is
challenging and relies largely on demonstration of elevated cardiac filling pressures …

This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …

In patients with left ventricular heart failure (HF), the development of pulmonary hypertension
(PH) and right ventricular (RV) dysfunction are frequent and have important impact on …

There is an unmet need for effective treatment strategies to reduce morbidity and mortality in
patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in …

Patients with heart failure with preserved ejection fraction (HFpEF) universally complain of
exercise intolerance and dyspnoea as key clinical correlates. Cardiac as well as …

Background Right ventricular (RV) dysfunction is recognized as a major prognostic factor in
left‐sided heart failure (HF). However, the relative contribution of RV dysfunction in HF with …