Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years …

Background Activation of the peripheral innate immune system stimulates the secretion of
CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Parkinson's disease (PD) is a common neurodegenerative movement disorder afflicting
millions of people in the United States. The advent of transgenic technologies has …

The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

Introduction 3. Basic aspects of adenosine as a neuromodulator relevant for cognitive
functions 4. Effects of adenosine receptor antagonists on cognitive deficits in aged rodents …

The administration of reserpine to rodents was one of the first models used to investigate the
pathophysiology and screening for potential treatments of P arkinson's disease (PD). The …

Brain monoamines play a key role in the regulation of behavior. Reserpine depletes
monoamines, and causes depression and hypoactivity in humans and rodents. In contrast, d …

Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's
disease (PD). However, in general, classic animal models are based on severe motor …