Transdifferentiation of epithelial cells into cells with mesenchymal properties and
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …

Traditional immunohistochemistry (IHC) has already become an essential method of
diagnosis and therapy in cancer management. However, this antibody-based technique is …

De novo and acquired resistance, which are largely attributed to genetic alterations, are
barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate …

Claudin-low breast cancer is a molecular type of breast cancer originally identified by gene
expression profiling and reportedly associated with poor survival. Claudin-low tumors have …

The current view of hematopoiesis considers leukocytes on a continuum with distinct
developmental origins, and which exert non-overlapping functions. However, there is less …

Multiplexed platforms for multiple epitope detection have emerged in the last years as very
powerful tools to study tumor tissues. These revolutionary technologies provide important …

Intestinal tuft cells are a rare, poorly understood cell type recently shown to be a critical
mediator of type 2 immune response to helminth infection. Here, we present advances in …

Non-muscle myosin IIA (NMIIA) protein plays an important role in cell cytokinesis and cell
migration. The role and underlying regulatory mechanisms of NMIIA in pancreatic cancer …

Zoonotic transmission of coronaviruses poses an ongoing threat to human populations.
Endemic outbreaks of swine acute diarrhea syndrome coronavirus (SADS-CoV) have …

Introduction: Metastasis and drug resistance contribute substantially to the poor prognosis of
colorectal cancer (CRC) patients. However, the epigenetic regulatory mechanisms by which …