The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …

Background Secukinumab, a fully human immunoglobulin G1-kappa monoclonal antibody
that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in the …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …

Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated
with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely …

Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
These are chronic autoimmune diseases of unknown etiology affecting the gastrointestinal …

Colorectal cancer (CRC) is one of the most common cancer worldwide. Chronic
inflammation contributes to CRC development and progression. Emodin, is a natural …

Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal
cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal …

Although colitis-associated cancer constitutes less than 2% of all colon cancers, 1 the
challenges associated with this type of this cancer have implications that relate to many …