Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …

Regenerative therapies for central nervous system diseases: a biomaterials approach

RY Tam, T Fuehrmann, N Mitrousis… - …, 2014 - nature.com
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

LH Nguyen, M Gao, J Lin, W Wu, J Wang, SY Chew - Scientific reports, 2017 - nature.com
Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in
axon regeneration. Unfortunately, currently established treatments, such as direct drug …

Combinatorial therapies after spinal cord injury: how can biomaterials help?

T Führmann, PN Anandakumaran… - Advanced healthcare …, 2017 - Wiley Online Library
Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function
below the injury site and is associated with a poor prognosis. The inhibitory environment that …

Injectable hydrogel materials for spinal cord regeneration: a review

D Macaya, M Spector - Biomedical materials, 2012 - iopscience.iop.org
Spinal cord injury (SCI) presents a complex regenerative problem due to the multiple facets
of growth inhibition that occur following trauma to the cord parenchyma and stroma …

Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury

H Suzuki, Y Imajo, M Funaba, H Ikeda… - International Journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological
deficit and social and financial burdens. It is currently being managed symptomatically, with …

Advances in fibrin-based materials in wound repair: a review

IS Bayer - Molecules, 2022 - mdpi.com
The first bioprocess that occurs in response to wounding is the deterrence of local
hemorrhage. This is accomplished by platelet aggregation and initiation of the hemostasis …

Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

M Yousefifard, V Rahimi-Movaghar, F Nasirinezhad… - Neuroscience, 2016 - Elsevier
Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum
protocol has been developed for application of neural stem/progenitor cells. In this regard …