Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This
review examines the fundamental pathogenetic mechanisms underlying this disorder, which …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

The premise that bones grow and remodel throughout life to adapt to their mechanical
enironment is often called Wolff's law. Wolff's law, however, is not always true, and in fact …

Bones are able to withstand functional loads without either breaking or sustaining extensive
damage because they have evolved the capacity to adapt their architecture in relation to …

A hypothesis is presented based on a coalescence of anthropological estimations of Homo
sapiens' phenotypes in the Late Paleolithic era 10,000 years ago, with Darwinian natural …

Bones serve several mechanical functions, including acoustic amplification in the middle
ear, shielding vital organs from trauma, and serving as levers for muscles to contract against …

We have developed a method to study the molecular basis of intramembranous fracture
healing. Unlike intramedullary rods that permit rotation of the fractured bone segments, our …

Bone is a remarkable tissue that can respond to external stimuli. The importance of
mechanical forces on the mass and structural development of bone has long been accepted …

Certain exercises can induce osteogenesis and improve bone strength, yet the biological
processes involved in bone mechanotransduction are only beginning to be understood …