New medications for drug addiction hiding in glutamatergic neuroplasticity

PW Kalivas, ND Volkow - Molecular psychiatry, 2011 - nature.com
The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …

[HTML][HTML] The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo

J Feng, K Chen, S Shen, Y Luo, X Liu, X Chen… - Biomedicine & …, 2023 - Elsevier
Corydalis yanhusuo WT Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one
of the herb components of many Chinese Traditional Medicine prescriptions such as Jin …

Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study

JE Grant, SR Chamberlain, BL Odlaug, MN Potenza… - …, 2010 - Springer
Rationale Although pathological gambling (PG) is relatively common, pharmacotherapy
research for PG is limited. Memantine, an N-methyl d-aspartate receptor antagonist, appears …

NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders

CF Zorumski, Y Izumi - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
N-methyl-d-aspartate receptors (NMDARs) are key components of neural signaling, playing
roles in synaptic transmission and in the synaptic plasticity thought to underlie learning and …

GluN3-containing NMDA receptors in the rat nucleus accumbens core contribute to incubation of cocaine craving

DT Christian, MT Stefanik, LA Bean… - Journal of …, 2021 - Soc Neuroscience
Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from
cocaine self-administration in rats and humans. In rats, the expression of incubation …

[HTML][HTML] Expression of NMDA receptor subunits in human blood lymphocytes: A peripheral biomarker in online computer game addiction

MS Sadat-Shirazi, N Vousooghi, B Alizadeh… - Journal of Behavioral …, 2018 - akjournals.com
Background and aims Repeated performance of some behaviors such as playing computer
games could result in addiction. The NMDA receptor is critically involved in the development …

The role of serine racemase in the pathophysiology of brain disorders

JT Coyle, DT Balu - Advances in pharmacology, 2018 - Elsevier
The N-methyl-d-aspartate receptor (NMDAR) is unique in requiring two agonists to bind
simultaneously to open its cation channel: the neurotransmitter, glutamate, and the …

Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans

F Mori, M Ribolsi, H Kusayanagi… - Journal of …, 2011 - journals.physiology.org
N-methyl-d-aspartate (NMDA) receptors play crucial roles in glutamate-mediated synaptic
transmission and plasticity and are involved in a variety of brain functions. Specific single …

Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons

YY Ma, C Cepeda, P Chatta, L Franklin… - ASN …, 2012 - journals.sagepub.com
The striatum can be divided into the DLS (dorsolateral striatum) and the VMS (ventromedial
striatum), which includes NAcC (nucleus accumbens core) and NAcS (nucleus accumbens …

[HTML][HTML] Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens

S Zappettini, M Grilli, G Olivero, J Chen… - Frontiers in Cellular …, 2014 - frontiersin.org
We here provide functional and immunocytochemical evidence supporting the co-
localization and functional interaction between nicotinic acetylcholine receptors (nAChRs) …