Physical activity is critically important for Type 2 diabetes management, yet adherence levels
are poor. This might be partly due to disproportionate exercise intolerance. Submaximal …

The prevalence of diabetes in the United States and globally has been rapidly increasing
over the last several decades. There are now estimated to be 30.3 million people in the …

Type 2 diabetes is associated with impaired exercise capacity. Alterations in both muscle
perfusion and mitochondrial function can contribute to exercise impairment. We …

Abstract Type 2 diabetes (T2D) has been rising in prevalence in the United States and
worldwide over the past few decades and contributes to significant morbidity and premature …

These studies test, using intravital microscopy (IVM), the hypotheses that perfusion effects
on insulin-stimulated muscle glucose uptake (MGU) are 1) capillary recruitment independent …

The rate-limiting step for skeletal muscle glucose uptake is transport from microcirculation to
muscle interstitium. Capillary endothelium poses a barrier that delays the onset of muscle …

OBJECTIVE Little is known about the extent to which microvascular disease is associated
with cardiorespiratory fitness (CRF) among individuals with type 2 diabetes. RESEARCH …

Aims Exercise capacity is impaired in type 2 diabetes, and this impairment predicts excess
morbidity and mortality. This defect appears to involve excess skeletal muscle …

Sepsis costs the healthcare system $23 billion annually and has a mortality rate between 10
and 40%. An early indication of sepsis is the onset of hyperglycemia, which is the result of …

The study of vascular function across conditions has been an intensive area of investigation
for many years. While these efforts have revealed many factors contributing to vascular …