Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups
Z Chen, B Wang, J Zhang, W Yu, Z Liu… - Organic Chemistry …, 2015 - pubs.rsc.org
Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …
strategies that is currently attracting tremendous attention with the aim to provide alternative …
The Homoaldol Reaction, or How to Overcome Problems of Regio‐and Stereo‐selectivity
D Hoppe - Angewandte Chemie International Edition in English, 1984 - Wiley Online Library
Even today, there are conspicuous gaps in the register of organic synthetic methods. Thus,
numerous types of homoenolate reagents are listed; yet no generally applicable method for …
numerous types of homoenolate reagents are listed; yet no generally applicable method for …
Directed ortho metalation. Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics
V Snieckus - Chemical Reviews, 1990 - ACS Publications
Studies on the structure, reactions, and synthesis of aromatic compounds are steeped inthe
history of or-ganic chemistry since the time of Kekule's dream a century ago. 1-2 Today, the …
history of or-ganic chemistry since the time of Kekule's dream a century ago. 1-2 Today, the …
Palladium-Catalyzed Ortho-Arylation of O-Phenylcarbamates with Simple Arenes and Sodium Persulfate
By palladium catalysis, the C− H bond functionalization of O-phenylcarbamates with simple
arenes has been achieved using sodium persulfate (Na2S2O8), an inexpensive, easy-to …
arenes has been achieved using sodium persulfate (Na2S2O8), an inexpensive, easy-to …
Pd-catalyzed ortho-arylation of phenylacetamides, benzamides, and anilides with simple arenes using sodium persulfate
We report a mild and efficient Pd-catalyzed ortho-arylation of phenylacetamides,
benzamides, and anilides with a range of simple arenes using sodium persulfate …
benzamides, and anilides with a range of simple arenes using sodium persulfate …
Directed ortho-meta′- and meta-meta′-dimetalations: A template base approach to deprotonation
AJ Martínez-Martínez, AR Kennedy, RE Mulvey… - Science, 2014 - science.org
The regioselectivity of deprotonation reactions between arene substrates and basic
metalating agents is usually governed by the electronic and/or coordinative characteristics of …
metalating agents is usually governed by the electronic and/or coordinative characteristics of …
Ring Walking Mediated by Ni–Ni Species as a Vehicle for Enabling Distal C(sp2)–H Functionalization of Aryl Pivalates
C Odena, E Gómez-Bengoa… - Journal of the American …, 2023 - ACS Publications
Herein, we report the utilization of Ni–Ni species as a manifold for enabling a “ring-walking”
event by dynamic translocation of the metal center over the arene backbone. Experimental …
event by dynamic translocation of the metal center over the arene backbone. Experimental …
Directed metalation of pi-deficient azaaromatics: Strategies of functionalization of pyridines, quinolines, and diazines
G Queguiner, F Marsais, V Snieckus… - Advances in heterocyclic …, 1991 - Elsevier
Publisher Summary This chapter updates the directed ortho metalation (DoM) reaction of
pyridines, quinolines, pyrimidines, pyrazines, and pyridazines. Various directed metalation …
pyridines, quinolines, pyrimidines, pyrazines, and pyridazines. Various directed metalation …
A practical in situ generation of the Schwartz reagent. Reduction of tertiary amides to aldehydes and hydrozirconation
Y Zhao, V Snieckus - Organic letters, 2014 - ACS Publications
A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH (OBu-t) 3) is described for the
generation of the Schwartz reagent which provides a convenient method for the amide to …
generation of the Schwartz reagent which provides a convenient method for the amide to …
Breaking the tert-Butyllithium Contact Ion Pair: A Gateway to Alternate Selectivity in Lithiation Reactions
The effects of Lewis basic phosphoramides on the aggregate structure of t-BuLi have been
investigated in detail by NMR and DFT methods. It was determined that …
investigated in detail by NMR and DFT methods. It was determined that …