Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …

Even today, there are conspicuous gaps in the register of organic synthetic methods. Thus,
numerous types of homoenolate reagents are listed; yet no generally applicable method for …

Studies on the structure, reactions, and synthesis of aromatic compounds are steeped inthe
history of or-ganic chemistry since the time of Kekule's dream a century ago. 1-2 Today, the …

By palladium catalysis, the C− H bond functionalization of O-phenylcarbamates with simple
arenes has been achieved using sodium persulfate (Na2S2O8), an inexpensive, easy-to …

We report a mild and efficient Pd-catalyzed ortho-arylation of phenylacetamides,
benzamides, and anilides with a range of simple arenes using sodium persulfate …

The regioselectivity of deprotonation reactions between arene substrates and basic
metalating agents is usually governed by the electronic and/or coordinative characteristics of …

Herein, we report the utilization of Ni–Ni species as a manifold for enabling a “ring-walking”
event by dynamic translocation of the metal center over the arene backbone. Experimental …

Publisher Summary This chapter updates the directed ortho metalation (DoM) reaction of
pyridines, quinolines, pyrimidines, pyrazines, and pyridazines. Various directed metalation …

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH (OBu-t) 3) is described for the
generation of the Schwartz reagent which provides a convenient method for the amide to …

The effects of Lewis basic phosphoramides on the aggregate structure of t-BuLi have been
investigated in detail by NMR and DFT methods. It was determined that …