Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

The inflammatory cytokine IL‐17 plays a critical role in immunity to infection and is involved
in the inflammatory pathology associated with certain autoimmune diseases, such as …

The increasing evidence that γδ T cells have potent antitumor activity suggests their value in
immunotherapy, particularly in areas of unmet need such as metastatic carcinoma. To this …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Increasing immunological knowledge and advances in techniques lay the ground for more
efficient and broader application of immunotherapies. gamma delta (γδ) T-cells possess …

The potent anti-tumour activities of γδ T cells have prompted the development of protocols in
which γδ-agonists are administered to cancer patients. Encouraging results from small …

While most T cells use a CD3-associated α/β T cell receptor as antigen recognition structure,
a second population of T cells expresses the alternative γ/δ T cell receptor. γ/δ T cells are a …

The mevalonate pathway for cholesterol biosynthesis and protein prenylation has been
implicated in various aspects of tumor development and progression. Certain classes of …

It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against
tumours not located in bone. Mice transgenic for the activated ErbB‐2 oncogene were …