The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer
effects; however, the underlying mechanism is poorly understood. Here we show that this …

Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well
as certain diabetes risk factors and treatments. This consensus statement of experts …

The increasing incidence of obesity and its co-morbid conditions poses a great challenge to
global health. In addition to cardiovascular disease and diabetes, epidemiological data …

Metformin, an insulin-lowering agent, has been associated with decreased cancer risk in
epidemiologic studies in diabetic patients. We performed a comprehensive literature search …

In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …

Abstract Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide
and a major economic burden. The prevalence of T2DM is rising, suggesting more effective …

Insulin treatment that mimics normal physiological patterns as closely as possible remains
the cardinal principle of treatment for type 1 diabetes. Since the last guidelines were …