Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?

W Jeong, J Bu, LJ Kubiatowicz, SS Chen, YS Kim… - Nano …, 2018 - Springer
Peptide–nanoparticle conjugates (PNCs) have recently emerged as a versatile tool for
biomedical applications. Synergism between the two promising classes of materials allows …

[HTML][HTML] Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction

W Ma, L Yang, L He - Journal of pharmaceutical analysis, 2018 - Elsevier
Drug-receptor interaction plays an important role in a series of biological effects, such as cell
proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the …

Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation

T Fujii, K Ito, K Takahashi, T Aoki… - ACS Medicinal …, 2023 - ACS Publications
Bispecific antibodies (BisAbs) are biotherapeutics that amalgamate the specificities of two
distinct antibodies into one molecule, however, their engineering requires genetic …

Enhanced EGFR targeting activity of plasmonic nanostructures with engineered GE11 peptide

F Biscaglia, S Rajendran, P Conflitti… - Advanced …, 2017 - Wiley Online Library
Plasmonic nanostructures show important properties for biotechnological applications, but
they have to be guided on the target for exploiting their potentialities. Antibodies are the …

Novel perspective for protein–drug interaction analysis: atomic force microscope

H Sun, J Wang - Analyst, 2023 - pubs.rsc.org
Proteins are major drug targets, and drug–target interaction identification and analysis are
important factors for drug discovery. Atomic force microscopy (AFM) is a powerful tool …

Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment: integrated computational analysis and in vitro study

A Hermawan, F Wulandari, N Hanif, RY Utomo… - Scientific Reports, 2022 - nature.com
The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the
brain, the limited capacity of brain cells to repair, resistance to conventional therapy, and its …

Biosensor-based active ingredients recognition system for screening STAT3 ligands from medical herbs

L Chen, D Lv, X Chen, M Liu, D Wang, Y Liu… - Analytical …, 2018 - ACS Publications
A surface plasmon resonance (SPR) biosensor-based active ingredients recognition system
(SPR-AIRS) was developed, validated, and applied to screen signal transducer and …

Characterization of EGF-guided MDA-MB-231 cell chemotaxis in vitro using a physiological and highly sensitive assay system

V Biswenger, N Baumann, J Jürschick, M Häckl… - PloS one, 2018 - journals.plos.org
Chemotactic cell migration is a central mechanism during cancer cell invasion and hence
metastasis. In order to mimic in vivo conditions, we used a three-dimensional hydrogel …

Biodistribution and activity of EGFR targeted polymeric micelles delivering a new inhibitor of DNA repair to Orthotopic colorectal Cancer xenografts with metastasis

IM de Paiva, MR Vakili, AH Soleimani… - Molecular …, 2022 - ACS Publications
The disruption of polynucleotide kinase/phosphatase (PNKP) in colorectal cancer (CRC)
cells deficient in phosphatase and tensin homolog (PTEN) is expected to lead to the loss of …

Evaluating the therapeutic efficacy of nano-drugs targeting epidermal growth factor receptor

J Zhao, S Li, X Pang, Y Shan - Chemical Communications, 2022 - pubs.rsc.org
Epidermal growth factor receptor (EGFR) targeted nano-drugs facilitate effective diagnosis
and treatment of cancer. Herein, the therapeutic efficacy of nano-drugs targeting EGFR was …