Immunomodulatory hydrogels: advanced regenerative tools for diabetic foot ulcer
Y Xiong, Q Feng, L Lu, K Zha, T Yu, Z Lin… - Advanced Functional …, 2023 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …
physical and mental challenges for patients due to the lack of efficient curative therapy …
Fibrinolytic serine proteases, therapeutic serpins and inflammation: fire dancers and firestorms
The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …
protease cascades are critical determinants of morbidity and mortality during infection and …
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection
SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung
inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal …
inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal …
Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins
Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate
serine proteases in the central coagulation and immune pathways, representing 2–10% of …
serine proteases in the central coagulation and immune pathways, representing 2–10% of …
Bioactive nanomaterials kickstart early repair processes and potentiate temporally modulated healing of healthy and diabetic wounds
Slow-healing and chronic wounds represent a major global economic and medical burden,
and there is significant unmet need for novel therapies which act to both accelerate wound …
and there is significant unmet need for novel therapies which act to both accelerate wound …
Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection
Immunopathogenesis in systemic viral infections can induce a septic state with leaky
capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment …
capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment …
Local serpin treatment via chitosan-collagen hydrogel after spinal cord injury reduces tissue damage and improves neurologic function
Spinal cord injury (SCI) results in massive secondary damage characterized by a prolonged
inflammation with phagocytic macrophage invasion and tissue destruction. In prior work …
inflammation with phagocytic macrophage invasion and tissue destruction. In prior work …
Deriving immune modulating drugs from viruses—a new class of biologics
Viruses are widely used as a platform for the production of therapeutics. Vaccines containing
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …
Compression Optical Coherence Elastography for Assessing Elasticity of the Vaginal Wall under Prolapse after Neodymium Laser Treatment
E Gubarkova, A Potapov, D Krupinova, K Shatilova… - Photonics, 2022 - mdpi.com
Early stages of pelvic organ prolapses are mainly associated with the pelvic floor disfunction
as a result of elasticity changes in the connective tissues including the vaginal wall. In this …
as a result of elasticity changes in the connective tissues including the vaginal wall. In this …
PEGylated serp-1 markedly reduces pristane-induced experimental diffuse alveolar hemorrhage, altering uPAR distribution, and macrophage invasion
Q Guo, JR Yaron, JW Wallen III, KF Browder… - Frontiers in …, 2021 - frontiersin.org
Diffuse alveolar hemorrhage (DAH) is one of the most serious clinical complications of
systemic lupus erythematosus (SLE). The prevalence of DAH is reported to range from 1 to …
systemic lupus erythematosus (SLE). The prevalence of DAH is reported to range from 1 to …