Biosensing with dnazymes

EM McConnell, I Cozma, Q Mou, JD Brennan… - Chemical Society …, 2021 - pubs.rsc.org
This article provides a comprehensive review of biosensing with DNAzymes, providing an
overview of different sensing applications while highlighting major progress and seminal …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Metal sensing by DNA

W Zhou, R Saran, J Liu - Chemical reviews, 2017 - ACS Publications
Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

DNAzymes as activity-based sensors for metal ions: recent applications, demonstrated advantages, current challenges, and future directions

RJ Lake, Z Yang, JJ Zhang, Y Lu - Accounts of chemical research, 2019 - ACS Publications
Conspectus Metal ions can be beneficial or toxic depending on their identity, oxidation state,
and concentration. Therefore, the ability to detect and quantify different types of metal ions …

Simultaneous Fe2+/Fe3+ imaging shows Fe3+ over Fe2+ enrichment in Alzheimer's disease mouse brain

Y Wu, SF Torabi, RJ Lake, S Hong, Z Yu, P Wu… - Science …, 2023 - science.org
Visualizing redox-active metal ions, such as Fe2+ and Fe3+ ions, are essential for
understanding their roles in biological processes and human diseases. Despite the …

Optical control of metal ion probes in cells and zebrafish using highly selective DNAzymes conjugated to upconversion nanoparticles

Z Yang, KY Loh, YT Chu, R Feng… - Journal of the …, 2018 - ACS Publications
Spatial and temporal distributions of metal ions in vitro and in vivo are crucial in our
understanding of the roles of metal ions in biological systems, and yet there is a very limited …

[HTML][HTML] Catalytic nucleic acids: biochemistry, chemical biology, biosensors, and nanotechnology

L Ma, J Liu - Iscience, 2020 - cell.com
Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been
used in different areas. Compared with protein enzymes, catalytic nucleic acids are …

Functional nucleic acid-based fluorescent probes for metal ion detection

J Xu, R Jiang, Y Feng, Z Liu, J Huang, C Ma… - Coordination Chemistry …, 2022 - Elsevier
Metal ions are ubiquitous elements within our environments. Their excessive accumulation
poses a great threat to human health. With the development of biology and bioanalytical …

Chemical and structural modification of RNA-cleaving DNAzymes for efficient biosensing and biomedical applications

Q Wang, Z Wang, Y He, B Xiong, Y Li… - TrAC Trends in Analytical …, 2023 - Elsevier
Deoxyribozyme (DNAzyme) is single-stranded catalytic DNA that possesses various
physical and chemical features, including small molecular weight, higher stability, excellent …