[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

JMGR de Morales, L Puig, E Daudén, JD Cañete… - Autoimmunity …, 2020 - Elsevier
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

Current concepts and advances in graft-versus-host disease immunology

GR Hill, BC Betts, V Tkachev, LS Kean… - Annual review of …, 2021 - annualreviews.org
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity

M Koyama, DS Hippe, S Srinivasan, SC Proll… - Immunity, 2023 - cell.com
Acute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic stem cell
transplantation (SCT), and severe intestinal manifestation is the major cause of early …

Gut microbiota injury in allogeneic haematopoietic stem cell transplantation

Y Shono, MRM van den Brink - Nature Reviews Cancer, 2018 - nature.com
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the
strongest curative immunotherapy for various malignancies (primarily, but not limited to …

[HTML][HTML] MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota

M Koyama, P Mukhopadhyay, IS Schuster, AS Henden… - Immunity, 2019 - cell.com
Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal
determinant of lethality following allogeneic bone marrow transplantation (BMT). Here, we …

Stool microbiota at neutrophil recovery is predictive for severe acute graft vs host disease after hematopoietic cell transplantation

JL Golob, SA Pergam, S Srinivasan… - Clinical Infectious …, 2017 - academic.oup.com
Background Graft-versus-host disease (GVHD) is common after allogeneic hematopoietic
cell transplantation (HCT). Risk for death from GVHD has been associated with low bacterial …

Cytokines and costimulation in acute graft-versus-host disease

GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

M Koyama, GR Hill - Blood, The Journal of the American …, 2019 - ashpublications.org
Allogeneic stem cell transplantation is a cornerstone of curative therapy for high-risk and/or
advanced hematological malignancies but remains limited by graft-versus-host disease …

The gut microbiota and graft-versus-host disease

DN Fredricks - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Graft-versus-host disease (GvHD) is a common complication of hematopoietic cell
transplantation that negatively impacts quality of life in recipients and can be fatal. Animal …

From osteoimmunology to osteomicrobiology: how the microbiota and the immune system regulate bone

E Hsu, R Pacifici - Calcified tissue international, 2018 - Springer
Osteomicrobiology refers to the role of microbiota in bone health and the mechanisms by
which the microbiota regulates post-natal skeletal development, bone aging, and pathologic …