EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation
C Zhang, Y Jin, M Marchetti, MR Lewis, OT Hammouda… - Current Biology, 2022 - cell.com
Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …
Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
A Kucharska, LK Rushworth, C Staples, NA Morrice… - Cellular signalling, 2009 - Elsevier
DUSP5 is an inducible, nuclear, dual-specificity phosphatase, which specifically interacts
with and inactivates the ERK1/2 MAP kinases in mammalian cells. In addition, expression of …
with and inactivates the ERK1/2 MAP kinases in mammalian cells. In addition, expression of …
[HTML][HTML] A Drosophila-centric view of protein tyrosine phosphatases
T Hatzihristidis, N Desai, AP Hutchins, TC Meng… - FEBS letters, 2015 - Elsevier
Most of our knowledge on protein tyrosine phosphatases (PTPs) is derived from human
pathologies and mouse knockout models. These models largely correlate well with human …
pathologies and mouse knockout models. These models largely correlate well with human …
Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
M Perander, R Al-Mahdi, TC Jensen, JAL Nunn… - Scientific reports, 2017 - nature.com
The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine
residue lying within the activation loop signature sequence SEG. However, the regulation of …
residue lying within the activation loop signature sequence SEG. However, the regulation of …
A mutation in the common docking domain of ERK2 in a human cancer cell line, which was associated with its constitutive phosphorylation
R Arvind, H Shimamoto, F Momose… - International …, 2005 - spandidos-publications.com
Abstract The EGFR/Ras/Raf/MEK/ERK pathway is a major pathway involved in the control of
growth signals, cell survival and differentiation. Mutations of signaling components, such as …
growth signals, cell survival and differentiation. Mutations of signaling components, such as …
New Negative Feedback Regulators of Egfr Signaling in Drosophila
JP Butchar, D Cain, SN Manivannan, AD McCue… - Genetics, 2012 - academic.oup.com
The highly conserved epidermal growth factor receptor (Egfr) pathway is required in all
animals for normal development and homeostasis; consequently, aberrant Egfr signaling is …
animals for normal development and homeostasis; consequently, aberrant Egfr signaling is …
Microarray analysis of drosophila EGF receptor signaling and cell line expression profiles
JP Butchar - 2006 - rave.ohiolink.edu
Despite the enormous advances in our understanding of the Drosophila Epidermal Growth
Factor Receptor signaling (dEgfr), it is evident that there are targets of this pathway that …
Factor Receptor signaling (dEgfr), it is evident that there are targets of this pathway that …