BACKGROUND The human brain contains about 100 billion neurons, each of which makes
thousands of synaptic connections. Although individual neurons can themselves be …

Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that
are related to the construction and refinement of functional networks. During the …

In most sensory modalities, neuronal connectivity reflects behaviorally relevant stimulus
features, such as spatial location, orientation, and sound frequency. By contrast, the …

The superior colliculus is a midbrain structure that plays important roles in visually guided
behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal …

INTRODUCTION Fundamental circuit features of the mouse visual system emerge before
the onset of vision, allowing the mouse to perceive objects and detect visual motion …

Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …

Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

Although a number of repair strategies have been shown to promote axon outgrowth
following neuronal injury in the mammalian CNS, it remains unclear whether regenerated …