Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

An increase in fat mass is considered to be an important risk factor for the worldwide
increase in type 2 diabetes and cardiovascular disease. However, for a given fat mass, there …

Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …

Elevated body mass index (BMI) is heritable and associated with many health conditions
that impact morbidity and mortality. The study of the genetic association of BMI across a …

Aims The potential difference in the impacts of lifestyle factors (LFs) on progression from
healthy to first cardiometabolic disease (FCMD), subsequently to cardiometabolic …

Aims The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our
primary aim was to apply the Mendelian randomization design to investigate the …

Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …

Background Obesity increases the risk of several chronic diseases, but the extent to which
the obesity-related loss of disease-free years varies by lifestyle category and across …

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants
to assess causal relationships between exposures and outcomes. MR studies can be …